Spitzer is a surname. Notable people with the surname include:
- Andre Spitzer (1945–1972), Israeli fencing coach and victim of the Munich massacre
 - Bernard Spitzer (1924–2014), American real estate developer and philanthropist, father of Eliot Spitzer
 - Eliot Spitzer (born 1959), 54th Governor of New York (2007–2008)
 - Frank Spitzer (1926–1992), Austrian-born American mathematician, author of Spitzer's formula
 - Frédéric Spitzer, 19th century art dealer, after whom the Spitzer Cross is named
 - Leo Spitzer (1887–1960), Austrian linguist
 - Lyman Spitzer (1914–1997), American theoretical physicist and mountaineer
 - Moritz Spitzer, scholar who gave his name to the Spitzer Manuscript
 - Robert Spitzer (priest) (born 1952), American Jesuit priest and president of Gonzaga University (1998–2009)
 - Robert R. Spitzer (1922–2019), American agricultural researcher and president of the Milwaukee School of Engineering (1977–1991)
 - Robert Spitzer (political scientist) (born 1953), American political scientist
 - Robert Spitzer (psychiatrist) (1932–2015), American psychiatrist
 - Toba Spitzer, American rabbi and president of the Reconstructionist Rabbinical Association (2007–2009)
 - Todd Spitzer (born 1960), district attorney of Orange County, California, since 2019 and member of the California State Assembly (2002–2008)
 - Šime Spitzer (1892–1941), Croatian Zionist
 - Simon Spitzer (1826–1887), Austrian mathematician
 - Walter Spitzer (1937–2006), Canadian epidemiologist and professor
 
See also
- All pages with titles containing Spitzer
 - Spitzer Space Telescope
 - Spitz (disambiguation)
 - Rudolf Lothar (born Rudolf Lothar Spitzer, 1865–1943), Hungarian-born Austrian writer, playwright, critic and essayist
 
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