Singles
2022 São Léo Open
Champion	Juan Pablo Varillas
Runner-up	Facundo Bagnis
Score	7–6(7–5), 4–6, 6–4

This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012.^[1]

Juan Pablo Varillas won the title after defeating Facundo Bagnis 7–6^(7–5), 4–6, 6–4 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	1	Facundo Bagnis	64	6	6
	4	Felipe Meligeni Alves	77	3	2
								1	Facundo Bagnis	65	6	4
								2	Juan Pablo Varillas	77	4	6
	Alt	Thiago Seyboth Wild	4	2
	2	Juan Pablo Varillas	6	6

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	F Bagnis	6	6
		P Boscardin Dias	4	2				1	F Bagnis	77	6
	Q	L Borg	1	2				WC	G Heide	64	3
	WC	G Heide	6	6											1	F Bagnis	6	6
	WC	J Fonseca	6	77											WC	J Fonseca	3	4
		TA Tirante	4	62				WC	J Fonseca	6	1	711
		M Navone	6	6					M Navone	3	6	69
	8	G Elias	4	4																		1	F Bagnis	64	6	6
	4	F Meligeni Alves	3	7	6																	4	F Meligeni Alves	77	3	2
		JB Torres	6	5	1			4	F Meligeni Alves	6	6
		GA Olivieri	5	4					N Álvarez	3	2
		N Álvarez	7	6											4	F Meligeni Alves	6	4	6
		F Comesaña	2	2												RA Burruchaga	1	6	3
		RA Burruchaga	6	6					RA Burruchaga	1	6	6
		G Villanueva	3	3				6	F Díaz Acosta	6	3	0
	6	F Díaz Acosta	6	6

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	R Olivo	4	6	3
	Q	M Alves	6	4	6			Q	M Alves	67	1
	Alt	JL Reis da Silva	6	6				Alt	JL Reis da Silva	79	6
	Q	JP Paz	3	2											Alt	JL Reis da Silva	2	5
		N Hardt	6	3	6										Alt	T Seyboth Wild	6	7
	Q	Wilson Leite	4	6	2				N Hardt	1	2
	Alt	T Seyboth Wild	78	5				Alt	T Seyboth Wild	6	6
	3	F Agamenone	66	1r																		Alt	T Seyboth Wild	4	2
	7/WC	M Pucinelli de Almeida	5	2																		2	JP Varillas	6	6
		D Dutra da Silva	7	6					D Dutra da Silva	2	6	6
		J Domingues	77	7					J Domingues	6	4	4
	Q	M Houkes	60	5												D Dutra da Silva	63	77	62
	Q	Damien Wenger	2	65											2	JP Varillas	77	64	77
		G Lama	6	77					G Lama	62	3
	LL	E Ribeiro	1	6	3			2	JP Varillas	77	6
	2	JP Varillas	6	4	6

References

External links

• Main draw
• Qualifying draw