ALG13
Identifiers
AliasesALG13, CDG1S, CXorf45, GLT28D1, MDS031, TDRD13, YGL047W, EIEE36, UDP-N-acetylglucosaminyltransferase subunit, ALG13 UDP-N-acetylglucosaminyltransferase subunit, DEE36
External IDsOMIM: 300776 HomoloGene: 78772 GeneCards: ALG13
Orthologs
SpeciesHumanMouse
Entrez

79868

n/a

Ensembl

ENSG00000101901

n/a

UniProt

Q9NP73

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr X: 111.67 – 111.76 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.[3][4]

Function

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.[3][5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101901 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 "Entrez Gene: asparagine-linked glycosylation 13 homolog (S. cerevisiae)".
  4. Gao XD, Tachikawa H, Sato T, Jigami Y, Dean N (October 2005). "Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation". J. Biol. Chem. 280 (43): 36254–62. doi:10.1074/jbc.M507569200. PMID 16100110.
  5. Averbeck N, Keppler-Ross S, Dean N (October 2007). "Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit". J. Biol. Chem. 282 (40): 29081–8. doi:10.1074/jbc.M704410200. PMID 17686769.

Further reading


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