AP3S1

AP3S1
Identifiers
Aliases	AP3S1, CLAPS3, Sigma3A, adaptor related protein complex 3 sigma 1 subunit, adaptor related protein complex 3 subunit sigma 1
External IDs	OMIM: 601507 MGI: 1337062 HomoloGene: 4254 GeneCards: AP3S1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	115,914,081 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	46,923,893 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; hippocampus proper; ; superior frontal gyrus; ; amygdala; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; ascending aorta; ; right coronary artery; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	ganglionic eminence; ; thymus; ; white adipose tissue; ; neural tube; ; ileum; ; mesencephalon; ; jejunum; ; ovary; ; pancreas; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; transporter activity;
Cellular component	AP-3 adaptor complex; membrane coat; Golgi apparatus; AP-type membrane coat adaptor complex; transport vesicle; cytoplasmic vesicle membrane; intracellular membrane-bounded organelle; membrane; cytoplasmic vesicle; axon cytoplasm;
Biological process	anterograde axonal transport; protein transport; insulin receptor signaling pathway; anterograde synaptic vesicle transport; intracellular protein transport; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	1176
	11777
	ENSG00000177879
	ENSMUSG00000024480
	Q92572
	Q9DCR2
NM_001002924; NM_001284; NM_001318090; NM_001318091; NM_001318093;
	NM_001318094
	NM_009681; NM_001303015
NP_001002924; NP_001275; NP_001305019; NP_001305020; NP_001305022;
	NP_001305023; NP_001351048; NP_001351049; NP_001351051
	NP_001289944; NP_033811
	Wikidata
View/Edit Human	View/Edit Mouse

AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177879 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024480 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Watanabe TK, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Sep 1996). "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain". Cytogenetics and Cell Genetics. 73 (3): 214–7. doi:10.1159/000134341. PMID 8697810.
↑ Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". The EMBO Journal. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692. PMID 9118953.
↑ "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit".

External links

Human AP3S1 genome location and AP3S1 gene details page in the UCSC Genome Browser.

Simpson F, Peden AA, Christopoulou L, Robinson MS (May 1997). "Characterization of the adaptor-related protein complex, AP-3". The Journal of Cell Biology. 137 (4): 835–45. doi:10.1083/jcb.137.4.835. PMC 2139840. PMID 9151686.
VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA (November 1998). "Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes". The Journal of Biological Chemistry. 273 (45): 29942–9. doi:10.1074/jbc.273.45.29942. PMID 9792713.
Rodionov DG, Höning S, Silye A, Kongsvik TL, von Figura K, Bakke O (December 2002). "Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3". The Journal of Biological Chemistry. 277 (49): 47436–43. doi:10.1074/jbc.M207149200. PMID 12370188.
Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (September 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Developmental Cell. 5 (3): 513–21. doi:10.1016/S1534-5807(03)00234-X. PMID 12967569.
Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V (February 2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation". Molecular Biology of the Cell. 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC 329249. PMID 14657250.
Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS (October 2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes". Developmental Cell. 7 (4): 619–25. doi:10.1016/j.devcel.2004.08.009. PMID 15469849.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177879 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024480 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8697810-5] Watanabe TK, Shimizu F, Nagata M, Takaichi A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Sep 1996). "Cloning, expression pattern and mapping to 12p 13.2 --> p13.1 of CLAPS3, a gene encoding a novel clathrin-adaptor small chain". Cytogenetics and Cell Genetics. 73 (3): 214–7. doi:10.1159/000134341. PMID 8697810.

[pmid9118953-6] Dell'Angelica EC, Ohno H, Ooi CE, Rabinovich E, Roche KW, Bonifacino JS (March 1997). "AP-3: an adaptor-like protein complex with ubiquitous expression". The EMBO Journal. 16 (5): 917–28. doi:10.1093/emboj/16.5.917. PMC 1169692. PMID 9118953.

[entrez-7] "Entrez Gene: AP3S1 adaptor-related protein complex 3, sigma 1 subunit".

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[5]

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References

External links

Further reading