ARF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARF4, ARF2, ADP ribosylation factor 4
External IDsOMIM: 601177 MGI: 99433 HomoloGene: 55593 GeneCards: ARF4
Orthologs
SpeciesHumanMouse
Entrez

378

11843

Ensembl

ENSG00000168374

ENSMUSG00000021877

UniProt

P18085

P61750

RefSeq (mRNA)

NM_001660

NM_007479

RefSeq (protein)

NP_001651

NP_031505

Location (UCSC)Chr 3: 57.57 – 57.6 MbChr 14: 26.36 – 26.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.[5][6]

Function

ADP-ribosylation factor 4 (ARF4) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1 and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. The ARF4 is the most divergent member of the human ARFs. Conflicting Map positions at 3p14 or 3p21 have been reported for this gene.[6]

Interactions

ARF4 has been shown to interact with Epidermal growth factor receptor[7] and with RVxP motifs.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168374 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021877 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Monaco L, Murtagh JJ, Newman KB, Tsai SC, Moss J, Vaughan M (Apr 1990). "Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2206–10. Bibcode:1990PNAS...87.2206M. doi:10.1073/pnas.87.6.2206. PMC 53655. PMID 2107548.
  6. 1 2 "Entrez Gene: ARF4 ADP-ribosylation factor 4".
  7. Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD (Jan 2003). "ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation". J. Biol. Chem. 278 (4): 2661–8. doi:10.1074/jbc.M205819200. PMID 12446727.
  8. Ward, Heather H.; Brown-Glaberman, Ursa; Wang, Jing; Morita, Yoshiko; Alper, Seth L.; Bedrick, Edward J.; Gattone, Vincent H.; Deretic, Dusanka; Wandinger-Ness, Angela (20 July 2011). "A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1". Molecular Biology of the Cell. 22 (18): 3289–3305. doi:10.1091/mbc.e11-01-0082. ISSN 1059-1524. PMC 3172256. PMID 21775626.

Further reading


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