ATP6V1G3
Identifiers
AliasesATP6V1G3, ATP6G3, Vma10, ATPase H+ transporting V1 subunit G3
External IDsOMIM: 618071 MGI: 2450548 HomoloGene: 13630 GeneCards: ATP6V1G3
Orthologs
SpeciesHumanMouse
Entrez

127124

338375

Ensembl

ENSG00000151418
ENSG00000263014

ENSMUSG00000026394

UniProt

Q96LB4

Q8BMC1

RefSeq (mRNA)

NM_177397

RefSeq (protein)

NP_796371

Location (UCSC)Chr 1: 198.52 – 198.54 MbChr 1: 138.2 – 138.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.[5][6]

Function

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. 1 2 3 ENSG00000263014 GRCh38: Ensembl release 89: ENSG00000151418, ENSG00000263014 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026394 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
  6. 1 2 "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3".


Further reading


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