Anna Seelig-Löffler
Anna Seelig-Löffler (2011)
NationalitySwiss
CitizenshipBasel
Scientific career
FieldsBiophysical chemist
InstitutionsBiozentrum University of Basel

Anna Seelig-Löffler is a Swiss Biophysical chemist who worked at the Biozentrum University of Basel, Switzerland.

Life

Anna Seelig-Löffler studied medicine and chemistry and received her PhD in physical chemistry from the University of Basel. As a postdoc she worked with Prof. Joachim Seelig. She then became an independent scientist in the Division of Biophysical Chemistry at the Biozentrum, habilitated in 1992, and later became honorary Professor of Biophysical Chemistry at the University of Basel. She reached emeritus status in 2012.[1]

Work

Her areas of expertise include the structural and functional analysis of membranes and their lipid and protein components.[2] More recently her work focused on ATP Binding Cassette (ABC)[3] transporters, such as P-glycoprotein, which prevent drug uptake across cell membranes and cause multidrug resistance. She discovered a universal substrate pattern for P-glycoprotein which made it possible to estimate the chance of a substrate to reach its target site.[4] Based on these findings she developed a model to predict drug uptake across biological membranes.[5]

Awards and honors

2008 STK Award of the Swiss Society for Thermal Analysis and Calorimetry [6]

References

  1. ↑ "Prof. Dr. Anna Seelig-Löffler, Titular Professor Emerita". biozentrum.unibas.ch. Retrieved 2022-02-09.
  2. ↑ Meier, M; Li-Blatter, Xiaochun; Seelig, Joachim; Seelig, Anna (15 October 2006). "Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity". Biophys J. 91 (8): 2943–55. doi:10.1529/biophysj.106.089581. PMC 1578493. PMID 16877510.
  3. ↑ Seelig, Anna; Li-Blatter, Xiaochun (1 January 2023). "P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport". Cancer Drug Resist. 6 (1): 1–29. doi:10.20517/cdr.2022.59. PMC 10105259. PMID 37070101.
  4. ↑ Seelig, Anna (15 January 1998). "A general pattern for substrate recognition by P-glycoprotein". Eur J Biochem. 251 (1–2): 252–61. doi:10.1046/j.1432-1327.1998.2510252.x. PMID 9492291.
  5. ↑ Assmus, Frauke; Ross, Alfred; Fischer, Holger; Seelig, Joachim; Seelig, Anna (2017-01-03). "31 P and 1 H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay". Mol Pharm. 14 (1): 284–295. doi:10.1021/acs.molpharmaceut.6b00889. PMID 27977215.
  6. ↑ "STK Awards". STK-online.ch. Retrieved 2014-03-24.
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