Anne Spang
Spang in 2015
Born (1967-11-29) 29 November 1967
Wadern
NationalityGerman
Scientific career
FieldsBiochemist/Cell Biologist
Institutions

Anne Spang (born 29 November 1967 in Wadern)[1] is a German Biochemist/Cell Biologist and Professor at the Biozentrum University of Basel, Switzerland.

Life

Anne Spang studied Chemical Engineering at the University of Applied Sciences in Darmstadt and Biochemistry at the University of Paris VI, France. She received her PhD in 1996 at the Max-Planck Institute of Biochemistry in Martinsried. She was then a postdoctoral fellow at the University of California, Berkeley, USA. From 1999 to 2006 she was an Independent Research Group Leader at the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen.[2] Since 2005 Anne Spang has held the position of Professor of Biochemistry and Cell Biology at the Biozentrum University of Basel.[3]

Work

Anne Spang investigates the basics of intracellular transport. Spang gained an international reputation through her discovery of the maturation process from early to late endosomes. In the nematode, Caenorhabditis elegans, she has identified the evolutionary conserved SAND-1 protein, which serves as the switch in Rab conversion during the maturation process.[4] In addition, her research has shown that ArfGAP proteins are important for the uptake of cargo into transport vesicles and that the small GTPase Arf1 and COPI components play a role in mRNA transport and mRNA metabolism.[5] Her research findings are significant for the understanding of many diseases which are based on the location of defects in protein and mRNA in the cell, such as cystic fibrosis and lysosomal storage disorders.[6]

Awards and honors

References

  1. ↑ "Bio Anne Spang". memim.com. Retrieved 15 July 2020.
  2. 1 2 "Profile Prof. Dr. Anne Spang". academia-net.org. Retrieved 11 July 2020.
  3. ↑ "Biozentrum Curriculum Vitae Anne Spang". biozentrum.unibas.ch. Retrieved 19 September 2023.
  4. ↑ Poteryaev, Dmitry; Datta, Sunando; Ackema, Karin; Zerial, Marino; Spang, Anne (2010). "Identification of the Switch in Early-to-Late Endosome Transition". Cell. cell.com. 141 (3): 497–508. doi:10.1016/j.cell.2010.03.011. PMID 20434987. S2CID 8430137.
  5. ↑ Estrada, Alejandro F.; Muruganandam, Gopinath; Prescianotto-Baschong, Cristina; Spang, Anne (2015). "The ArfGAP2/3 Glo3 and ergosterol collaborate in transport of a subset of cargoes". Biology Open. bio.biologists.org. 4 (7): 792–802. doi:10.1242/bio.011528. PMC 4571087. PMID 25964658. Retrieved 11 July 2020.
  6. ↑ Kilchert, C.; Weidner, J.; Prescianotto-Baschong, C.; Spang, A. (2010). "Defects in the Secretory Pathway and High Ca2+ Induce Multiple P-bodies". Molecular Biology of the Cell. nih.gov. 21 (15): 2624–2638. doi:10.1091/mbc.e10-02-0099. PMC 2912349. PMID 20519435.
  7. ↑ "List of members, Prof. Dr. Anne Spang". leopoldina.org. Retrieved 19 September 2023.
  8. ↑ "BINDER Innovation Prize 2010". pressebox.com. Retrieved 11 July 2020.
  9. ↑ "Bio Anne Spang". frontiersin.org. Retrieved 11 July 2020.
  10. ↑ EMBO Annual Report Archived 11 June 2012 at the Wayback Machine (PDF; 1,5 MB)
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