Brain-specific angiogenesis inhibitor 3

ADGRB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DLO
Identifiers
Aliases	ADGRB3, BAI3, adhesion G protein-coupled receptor B3
External IDs	OMIM: 602684 MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	69,390,571 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	25,868,788 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; Brodmann area 23; ; orbitofrontal cortex; ; superior frontal gyrus; ; Brodmann area 46; ; postcentral gyrus; ; entorhinal cortex; ; Region I of hippocampus proper; ; prefrontal cortex;
	Top expressed in
	nucleus accumbens; ; olfactory tubercle; ; ventromedial nucleus; ; cerebellar vermis; ; medial geniculate nucleus; ; subiculum; ; Region I of hippocampus proper; ; piriform cortex; ; substantia nigra; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity; signal transducer activity; GTPase activator activity;
Cellular component	integral component of membrane; plasma membrane; membrane; postsynapse; synaptic cleft; intracellular anatomical structure; integral component of plasma membrane;
Biological process	negative regulation of angiogenesis; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cell surface receptor signaling pathway; myoblast fusion; signal transduction; positive regulation of synapse assembly; regulation of dendrite morphogenesis; motor learning; maintenance of synapse structure; neuron remodeling; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	577
	210933
	ENSG00000135298
	ENSMUSG00000033569
	O60242
	Q80ZF8
	NM_001704
	NM_175642
	NP_001695
	NP_783573
	Wikidata
View/Edit Human	View/Edit Mouse

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.^[5]^[6]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.^[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.^[7]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.^[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135298 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033569 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108. doi:10.1159/000134693. PMID 9533023.
1 2 "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
↑ Lanoue, V; Usardi, A; Sigoillot, S M; Talleur, M; Iyer, K; Mariani, J; Isope, P; Vodjdani, G; Heintz, N; Selimi, F (2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18 (8): 943–950. doi:10.1038/mp.2013.46. PMC 3730300. PMID 23628982.
↑ Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539. Bibcode:2011PNAS..108.2534B. doi:10.1073/pnas.1019577108. PMC 3038708. PMID 21262840.

External links

Human ADGRB3 genome location and ADGRB3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135298 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033569 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9533023-5] Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108. doi:10.1159/000134693. PMID 9533023.

[entrez-6] 1 2 "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".

[7] Lanoue, V; Usardi, A; Sigoillot, S M; Talleur, M; Iyer, K; Mariani, J; Isope, P; Vodjdani, G; Heintz, N; Selimi, F (2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18 (8): 943–950. doi:10.1038/mp.2013.46. PMC 3730300. PMID 23628982.

[8] Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539. Bibcode:2011PNAS..108.2534B. doi:10.1073/pnas.1019577108. PMC 3038708. PMID 21262840.

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References

Further reading

External links