| GPR12 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 600752 MGI: 101909 HomoloGene: 3868 GeneCards: GPR12 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[5][6][7]
The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[8]
Ligands
- Inverse agonists
Evolution
Paralogues
Source:[10]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000132975 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041468 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi:10.1016/0014-5793(93)80828-I. PMID 8262253. S2CID 31345248.
- ↑ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
- ↑ "Entrez Gene: GPR12 G protein-coupled receptor 12".
- ↑ Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
- ↑ Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771. PMID 28888984.
- ↑ "GeneCards®: The Human Gene Database".
Further reading
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