Bruce H. Lipshutz (born 1951) is an American chemist. He is a professor at the University of California, Santa Barbara.[1]

Biography

Lipshutz received his undergraduate degree in chemistry from Binghamton University in 1973. His graduate work was supervised by Harry H. Wasserman at Yale. After a PhD degree in 1977, he spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award.[2] He is Co-founder of Zymes LLC.[3]

Contributions

Reagents

Methodologies

  • Higher-order organocuprates (Lipshutz cuprates).[12]
  • Chiral and achiral conjugate reductions.
  • Catalyst development for ppm Pd-catalyzed C-C couplings in water at ambient[13][14]
  • Use of nonionic amphiphiles for transition metal-mediated cross coupling in organic synthesis.[15]
  • Low-cost synthesis of Coenzyme Q10.[16][17]

References

  1. ↑ "People | Department of Chemistry - UC Santa Barbara". www.chem.ucsb.edu.
  2. ↑ "Past Award Entries and Recipients | Green Chemistry | US EPA". Retrieved 12 August 2023.
  3. ↑ "Zymes llc". Archived from the original on July 17, 2008.
  4. ↑ TPGS-750-M: A Second-Generation Amphiphile for Metal-Catalyzed Cross-Couplings in Water at Room Temperature
  5. ↑ “Nok”: A Phytosterol-Based Amphiphile Enabling Transition-Metal-Catalyzed Couplings in Water at Room Temperature
  6. ↑ Sustainable Fe–ppm Pd nanoparticle catalysis of Suzuki-Miyaura cross-couplings in water
  7. ↑ HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature
  8. ↑ β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group
  9. ↑ Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate
  10. ↑ (BDP)CuH: A "Hot" Stryker's reagent for Use in Achiral Conjugate Reductions
  11. ↑ Asymmetric Hydrosilylation of Aryl Ketones Catalyzed by Copper Hydride Complexed by Nonracemic Biphenyl Bis-phosphine Ligands
  12. ↑ Bruce H. Lipshutz, Robert Moretti, Robert Crow "Mixed Higher-order Cyanocuprate-induced Epoxide Openings: 1-Benzyloxy-4-penten-2-ol" Org. Synth. 1990, volume 69, pp. 80. {{DOI:10.15227/orgsyn.069.0080}}
  13. ↑ Handa, Sachin; Andersson, Martin P.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. (2016). "Handa Phos: A General Ligand Enabling Sustainable PPM Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature". Angewandte Chemie International Edition. 55 (16): 4914–4918. doi:10.1002/anie.201510570. PMC 4966530. PMID 26924396.
  14. ↑ Landstrom, Evan B.; Handa, Sachin; Aue, Donald H.; Gallou, Fabrice; Lipshutz, Bruce H. (2018). "Evan Phos: A ligand for PPM level Pd-catalyzed Suzuki–Miyaura couplings in either organic solvent or water". Green Chemistry. 20 (15): 3436–3443. doi:10.1039/C8GC01356J.
  15. ↑ "Merck KGaA". Archived from the original on 2016-11-12. Retrieved 2019-06-16.
  16. ↑ "NSF - OLPA - News Tip: November 29, 2002". www.nsf.gov.
  17. ↑ Lipshutz, Bruce H.; Lower, Asher; Berl, Volker; Schein, Karin; Wetterich, Frank (2005). "An Improved Synthesis of the "Miracle Nutrient" Coenzyme Q10". Organic Letters. 7 (19): 4095–4097. doi:10.1021/ol051329y. PMID 16146360.
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