CARD10
Identifiers
AliasesCARD10, BIMP1, CARMA3, caspase recruitment domain family member 10, IMD89
External IDsOMIM: 607209 MGI: 2146012 HomoloGene: 8728 GeneCards: CARD10
Orthologs
SpeciesHumanMouse
Entrez

29775

105844

Ensembl

ENSG00000100065

ENSMUSG00000033170

UniProt

Q9BWT7

P58660

RefSeq (mRNA)

NM_014550

NM_130859

RefSeq (protein)

NP_055365

NP_570929

Location (UCSC)Chr 22: 37.49 – 37.52 MbChr 15: 78.66 – 78.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene.[5][6][7]

Function

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM][7]

Interactions

CARD10 has been shown to interact with BCL10.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100065 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033170 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
  6. Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
  7. 1 2 "Entrez Gene: CARD10 caspase recruitment domain family, member 10".
  8. Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

Further reading


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