CCT2
Identifiers
AliasesCCT2, 99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta, chaperonin containing TCP1 subunit 2
External IDsOMIM: 605139 MGI: 107186 HomoloGene: 4696 GeneCards: CCT2
Orthologs
SpeciesHumanMouse
Entrez

10576

12461

Ensembl

ENSG00000166226

ENSMUSG00000034024

UniProt

P78371

P80314

RefSeq (mRNA)

NM_006431
NM_001198842

NM_007636
NM_001358767

RefSeq (protein)

NP_001185771
NP_006422

NP_031662
NP_001345696

Location (UCSC)Chr 12: 69.59 – 69.6 MbChr 10: 116.89 – 116.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene.[5][6]

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.[6]

Interactions

CCT2 (gene) has been shown to interact with PPP4C.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166226 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034024 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
  6. 1 2 "Entrez Gene: CCT2 chaperonin containing TCP1, subunit 2 (beta)".
  7. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  8. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Further reading


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