CCT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCT3, CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5, chaperonin containing TCP1 subunit 3
External IDsOMIM: 600114 MGI: 104708 HomoloGene: 4373 GeneCards: CCT3
Orthologs
SpeciesHumanMouse
Entrez

7203

12462

Ensembl

ENSG00000163468

ENSMUSG00000001416

UniProt

P49368
Q5SZW8

P80318

RefSeq (mRNA)

NM_001008800
NM_001008883
NM_005998

NM_009836

RefSeq (protein)

NP_001008800
NP_005989

NP_033966

Location (UCSC)Chr 1: 156.31 – 156.37 MbChr 3: 88.2 – 88.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.[5][6]

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Interactions

CCT3 has been shown to interact with PPP4C.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163468 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001416 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V (Mar 1994). "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.
  6. 1 2 "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".
  7. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  8. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Further reading


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