CIDEB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCIDEB, cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b
External IDsOMIM: 604441 MGI: 1270844 HomoloGene: 7666 GeneCards: CIDEB
Orthologs
SpeciesHumanMouse
Entrez

27141

12684

Ensembl

ENSG00000136305
ENSG00000285199

ENSMUSG00000022219

UniProt

Q9UHD4

O70303

RefSeq (mRNA)

NM_014430
NM_001318807

NM_009894
NM_026804

RefSeq (protein)

NP_001305736
NP_055245

NP_034024

Location (UCSC)Chr 14: 24.31 – 24.31 MbChr 14: 55.99 – 56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.[5][6][7]

In humans, individuals carrying rare loss of function mutations in the CIDEB gene are protected against different aetiologies of liver disease.[8] CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[9] CIDEB plays a key role in determining lipid droplet size: overexpression of CIDEB in vitro results in fat accumulation by inducing larger lipid droplets, while CIDEB knock-out experiments results in accumulation of smaller lipid droplets.[10][8]

References

  1. 1 2 3 ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022219 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b".
  6. ↑ Ye J, Zhong Li J, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B." Cell Metabolism. 9 (2): 177–190. doi:10.1016/j.cmet.2008.12.013. PMID 19187774.
  7. ↑ Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (5): 577–86. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.
  8. 1 2 Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, De T, Hindy G, Bovijn J, Persaud T, Miloscio L, Germino M, Panagis L, Watanabe K, Mbatchou J (2022-07-28). "Germline Mutations in CIDEB and Protection against Liver Disease". New England Journal of Medicine. 387 (4): 332–344. doi:10.1056/NEJMoa2117872. ISSN 0028-4793. PMID 35939579. S2CID 251143047.
  9. ↑ Zhong Li J, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation". Diabetes. 56 (10): 2523–2532. doi:10.2337/db07-0040. PMID 17646209.
  10. ↑ Xu W, Wu L, Yu M, Chen F, Arshad M, Xia X, Ren H, Yu J, Xu L, Xu D, Li JZ, Li P, Zhou L (2016-02-26). "Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes". The Journal of Biological Chemistry. 291 (9): 4282–4293. doi:10.1074/jbc.M115.701094. ISSN 1083-351X. PMC 4813457. PMID 26733203.

Further reading



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