COG3
Identifiers
AliasesCOG3, SEC34, component of oligomeric golgi complex 3
External IDsOMIM: 606975 MGI: 2450151 HomoloGene: 5854 GeneCards: COG3
Orthologs
SpeciesHumanMouse
Entrez

83548

338337

Ensembl

ENSG00000136152

ENSMUSG00000034893

UniProt

Q96JB2

Q8CI04

RefSeq (mRNA)

NM_001204476
NM_031431

NM_177381

RefSeq (protein)

NP_113619

n/a

Location (UCSC)Chr 13: 45.46 – 45.54 MbChr 14: 75.94 – 75.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.[5][6]

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[6]

Interactions

COG3 has been shown to interact with COG2[7] and COG1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136152 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034893 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". The Journal of Cell Biology. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  6. 1 2 "Entrez Gene: COG3 component of oligomeric golgi complex 3".
  7. 1 2 Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.

Further reading


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