Collagen, type XXV, alpha 1

COL25A1
Identifiers
Aliases	COL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDs	OMIM: 610004 MGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	109,302,752 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	130,393,526 bp
RNA expression pattern
	Top expressed in
	sperm; ; jejunal mucosa; ; Achilles tendon; ; subcutaneous adipose tissue; ; anterior pituitary; ; sural nerve; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; gallbladder; ; hypothalamus;
	Top expressed in
	median eminence; ; medial dorsal nucleus; ; arcuate nucleus; ; substantia nigra; ; habenula; ; superior colliculus; ; lateral geniculate nucleus; ; lateral hypothalamus; ; ventromedial nucleus; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparin binding; amyloid-beta binding; extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength;
Cellular component	integral component of membrane; extracellular region; plasma membrane; collagen; endoplasmic reticulum lumen; membrane; extracellular space; integral component of plasma membrane; extracellular matrix; collagen-containing extracellular matrix;
Biological process	axonogenesis involved in innervation; extracellular matrix organization;
	Sources:Amigo / QuickGO
Orthologs
	84570
	77018
	ENSG00000188517
	ENSMUSG00000058897
	Q9BXS0
	Q99MQ5
	NM_001256074; NM_032518; NM_198721
	NM_001244952; NM_029838; NM_198711
	NP_001243003; NP_115907; NP_942014
	NP_001231881; NP_084114; NP_942004
	Wikidata
View/Edit Human	View/Edit Mouse

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.^[5]^[6]

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM]^[6]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000188517 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058897 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537.
1 2 "Entrez Gene: COL25A1 collagen, type XXV, alpha 1".

Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation". Biochemistry. 44 (47): 15602–9. doi:10.1021/bi051263e. PMID 16300410.
Söderberg L, Dahlqvist C, Kakuyama H, et al. (2005). "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates". FEBS J. 272 (9): 2231–6. doi:10.1111/j.1742-4658.2005.04647.x. hdl:10616/39314. PMID 15853808. S2CID 26505595.
Osada Y, Hashimoto T, Nishimura A, et al. (2005). "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils". J. Biol. Chem. 280 (9): 8596–605. doi:10.1074/jbc.M413340200. PMID 15615705.
Söderberg L, Kakuyama H, Möller A, et al. (2005). "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site". J. Biol. Chem. 280 (2): 1007–15. doi:10.1074/jbc.M403628200. PMID 15522881.
Kowa H, Sakakura T, Matsuura Y, et al. (2004). "Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits". Am. J. Pathol. 165 (1): 273–81. doi:10.1016/s0002-9440(10)63295-6. PMC 1618534. PMID 15215182.
Söderberg L, Zhukareva V, Bogdanovic N, et al. (2004). "Molecular identification of AMY, an Alzheimer disease amyloid-associated protein". J. Neuropathol. Exp. Neurol. 62 (11): 1108–17. doi:10.1093/jnen/62.11.1108. PMID 14656069.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000188517 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058897 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11927537-5] 1 2 Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537.

[entrez-6] 1 2 "Entrez Gene: COL25A1 collagen, type XXV, alpha 1".

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Interactions

References

Further reading