Introduction

Complex Proteins Associated with Set1, also known as COMPASS, is a conserved protein complex playing a major role as a H3K4me3 methylase in eukaryotes.[1] Since it was first identified in 2001,[2] other members of the COMPASS family of methylases with different functions have been discovered, in particular in humans.[1]

The COMPASS complex, or similar protein complexes, have been identified in species ranging from single-celled fungi to humans.[3] They play an important regulatory role in many essential biological processes including DNA repair, the progression of the cell cycle, and transcription through the methylenation of histone lysines.[3]

The COMPASS complex is an example of a trithorax-group protein.[1] The MLL1/SET domain associated with the COMPASS complex have crystal structure.[3] The gene Cps50 coordinates the construction of COMPASS.[4]

References

  1. 1 2 3 Shilatifard, Ali (December 10, 2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual Review of Biochemistry. 81 (1): 65–95. doi:10.1146/annurev-biochem-051710-134100. PMC 4010150. PMID 22663077.
  2. ↑ Miller, Trissa; Krogan, Nevan J.; Dover, Jim; Erdjument-Bromage, H.; Tempst, Paul; Johnston, Mark; Greenblatt, Jack F.; Shilatifard, Ali (November 6, 2001). "COMPASS: A complex of proteins associated with a trithorax-related SET domain protein". Proceedings of the National Academy of Sciences. 98 (23): 12902–12907. Bibcode:2001PNAS...9812902M. doi:10.1073/pnas.231473398. PMC 60797. PMID 11687631.
  3. 1 2 3 Takahashi, Yoh-hei; Westfield, Gerwin H.; Oleskie, Austin N.; Trievel, Raymond C.; Shilatifard, Ali; Skiniotis, Georgios (2011-12-20). "Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human". Proceedings of the National Academy of Sciences. 108 (51): 20526–20531. doi:10.1073/pnas.1109360108. ISSN 0027-8424. PMC 3251153. PMID 22158900.
  4. ↑ Qu, Qianhui; Takahashi, Yoh-hei; Yang, Yidai; Hu, Hongli; Zhang, Yan; Brunzelle, Joseph S.; Couture, Jean-Francois; Shilatifard, Ali; Skiniotis, Georgios (2018-08-23). "Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex". Cell. 174 (5): 1117–1126.e12. doi:10.1016/j.cell.2018.07.020. ISSN 0092-8674. PMC 6108936. PMID 30100186.


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