| CRLF3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614853 MGI: 1860086 HomoloGene: 9327 GeneCards: CRLF3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[5]
Function
Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.[6]
Origin
Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.[7][8]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000176390 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017561 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: cytokine receptor-like factor 3".
- ↑ Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, et al. (2017). "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor". Frontiers in Molecular Neuroscience. 10: 223. doi:10.3389/fnmol.2017.00223. PMC 5509957. PMID 28769759.
- ↑ Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, et al. (2019). "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience. 12: 251. doi:10.3389/fnmol.2019.00251. PMC 6797617. PMID 31680856.
- ↑ Liongue C, Ward AC (July 2007). "Evolution of Class I cytokine receptors". BMC Evolutionary Biology. 7 (1): 120. doi:10.1186/1471-2148-7-120. PMC 1963337. PMID 17640376.
External links
- Human CRLF3 genome location and CRLF3 gene details page in the UCSC Genome Browser.
Further reading
- Visser R, Koelma N, Vijfhuizen L, van der Wielen MJ, Kant SG, Breuning MH, et al. (February 2009). "RNF135 mutations are not present in patients with Sotos syndrome-like features". American Journal of Medical Genetics. Part A. 149A (4): 806–8. doi:10.1002/ajmg.a.32694. PMID 19291764. S2CID 10349510.
- Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, et al. (May 2008). "Many sequence variants affecting diversity of adult human height". Nature Genetics. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951. S2CID 3005450.
- Zhao J, Li M, Bradfield JP, Zhang H, Mentch FD, Wang K, et al. (June 2010). "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature". BMC Medical Genetics. 11: 96. doi:10.1186/1471-2350-11-96. PMC 2894790. PMID 20546612.
- Yang F, Xu YP, Li J, Duan SS, Fu YJ, Zhang Y, et al. (November 2009). "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression". The International Journal of Biochemistry & Cell Biology. 41 (11): 2240–50. doi:10.1016/j.biocel.2009.04.022. PMID 19427400.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, et al. (July 2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLOS Genetics. 6 (7): e1001016. doi:10.1371/journal.pgen.1001016. PMC 2900295. PMID 20628624.
- Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
- Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, et al. (August 2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nature Genetics. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.
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