| CHST13 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CHST13, C4ST3, carbohydrate sulfotransferase 13, Carbohydrate (chondroitin 4) sulfotransferase 13 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610124 MGI: 1919047 HomoloGene: 44360 GeneCards: CHST13 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Carbohydrate (chondroitin 4) sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.[5]
Function
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000180767 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056643 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: Carbohydrate (chondroitin 4) sulfotransferase 13".
Further reading
- Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (September 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". The Journal of Biological Chemistry. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.
- Valente B, Campos PA, do Rosário VE, Silveira H (October 2010). "Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene. 104 (10): 687–9. doi:10.1016/j.trstmh.2010.05.005. PMID 20580388.
- Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (June 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID 10781601.
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