Clovibactin
Identifiers
  • (3S,6S,9S,13R)-12-[[(2S)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-9-methyl-3,6-bis(2-methylpropyl)-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecane-13-carboxamide
CAS Number
PubChem CID
Chemical and physical data
FormulaC43H70N10O11
Molar mass903.092 g·mol−1
3D model (JSmol)
  • CC(C)C[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NC1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O[C@H]1C(N)=O
  • InChI=1S/C43H70N10O11/c1-22(2)17-29-40(60)51-31(19-24(5)6)43(63)64-34(35(46)55)33(42(62)47-25(7)36(56)49-29)53-41(61)32(21-54)52-38(58)28(15-11-12-16-44)48-39(59)30(18-23(3)4)50-37(57)27(45)20-26-13-9-8-10-14-26/h8-10,13-14,22-25,27-34,54H,11-12,15-21,44-45H2,1-7H3,(H2,46,55)(H,47,62)(H,48,59)(H,49,56)(H,50,57)(H,51,60)(H,52,58)(H,53,61)/t25-,27-,28+,29-,30+,31-,32-,33?,34+/m0/s1
  • Key:SMQAHGKBWXPEHB-MJGFNNBQSA-N

Clovibactin (Novo29) is an experimental antibiotic isolated from an uncultured soil Gram-negative β-proteobacterium Eleftheria terrae ssp. carolina, which is one of many soil bacteria.[1][2]

See also

References

  1. ↑ Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MG, de Benedetti S, et al. (August 22, 2023). "An antibiotic from an uncultured bacterium binds to an immutable target". Cell. 186 (19): 4059–4073.e27. doi:10.1016/j.cell.2023.07.038. PMID 37611581. Preprint:
    Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MG, de Benedetti S, et al. (May 2023). "A new antibiotic from an uncultured bacterium binds to an immutable target". bioRxiv. doi:10.1101/2023.05.15.540765. PMC 10245560. PMID 37292624.
  2. ↑ Krumberger M, Li X, Kreutzer AG, Peoples AJ, Nitti AG, Cunningham AM, et al. (February 2023). "Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29". The Journal of Organic Chemistry. 88 (4): 2214–2220. doi:10.1021/acs.joc.2c02648. PMC 9942206. PMID 36655882.
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