Copper naproxen

Sample of copper naproxen in a glass vial
Names
Other names
Copper(II) 6-methoxy-a-methyl-2-naphthaleneacetate
Identifiers
Properties
C28H26CuO6
Molar mass 522.056 g·mol−1
Appearance Green solid
Solubility Soluble in methanol, 1,4-dioxane,[1] DMSO, DMF[2]
Related compounds
Related compounds
 Copper aspirinate
Copper ibuprofenate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Copper naproxen is a chemical complex of copper2+ chelated with the anti-inflammatory drug naproxen.[1] Copper complexes of NSAIDs like naproxen have been shown to have greater anti-inflammatory properties than the base drug.[3][2]

Copper naproxen can by found as a monohydrate, and it can form complexes with other organic molecules such as nicotinyl alcohol, 3-methylpyridine, and caffeine.[1][4][5]

Preparation

Copper naproxen is prepared by reacting sodium naproxen with a copper(II) salt such as copper(II) sulfate.[1]

References

  1. 1 2 3 4 Melnı́k, Milan; Macásková, Lubov; Holloway, Clive E; Mrozinski, Jerzy; Kalin’ska, Bozena (March 2000). "Spectral and magnetic properties of copper(II) naproxenates". Inorganica Chimica Acta. 299 (2): 284–287. doi:10.1016/S0020-1693(99)00504-6.
  2. 1 2 Dimiza, Filitsa; Perdih, Franc; Tangoulis, Vassilis; Turel, Iztok; Kessissoglou, Dimitris P.; Psomas, George (March 2011). "Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding". Journal of Inorganic Biochemistry. 105 (3): 476–489. doi:10.1016/j.jinorgbio.2010.08.013.
  3. ↑ Sorenson, John R.J. (1989), 6 Copper Complexes Offer a Physiological Approach to Treatment of Chronic Diseases, Progress in Medicinal Chemistry, vol. 26, Elsevier, pp. 437–568, doi:10.1016/s0079-6468(08)70246-7, ISBN 978-0-444-81038-0, retrieved 2022-04-10
  4. ↑ Caglar, Sema; Adiguzel, Ekrem; Sariboga, Bahtiyar; Temel, Ersin; Buyukgungor, Orhan (2014-02-16). "Mono and dinuclear copper(II) naproxenato complexes containing 3-picoline and 4-picoline: synthesis, structure, properties, catechol oxidase, and antimicrobial activities". Journal of Coordination Chemistry. 67 (4): 670–683. doi:10.1080/00958972.2014.891198. ISSN 0095-8972. S2CID 96991445.
  5. ↑ Abuhijleh, A. Latif; Khalaf, Juhienah (September 2010). "Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase – mimetic activities". European Journal of Medicinal Chemistry. 45 (9): 3811–3817. doi:10.1016/j.ejmech.2010.05.031. PMID 20605277.
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