Cosimo Commisso is a Canadian cell biologist and cancer researcher who has made significant advances in the field of cellular trafficking and cancer metabolism.[1][2][3] Among his most notable contributions are the discovery and study of how macropinocytosis supports tumor cell growth and survival by serving as an amino acid supply route in Ras-mutated cancers.[4][5][6] He is currently an associate professor in the Tumor Initiation and Maintenance Program at the Sanford Burnham Prebys Medical Discovery Institute NCI-designated Cancer Center in La Jolla, California, USA.

References

  1. ↑ Trading, American Laboratory. "DR. COSIMO COMMISSO AND THE NUTRIENT SCAVENGERS". americanlaboratorytrading.com. Retrieved 2017-11-20.
  2. ↑ "2015 Grant Recipient Cosimo Commisso, PhD – Pancreatic Cancer Action Network". Pancreatic Cancer Action Network. Retrieved 2017-11-20.
  3. ↑ Action, Pancreatic Cancer (2013-05-27). "New understanding of nutrient uptake in Pancreatic Cancer cells could lead to future drug targets · Pancreatic Cancer Action". Pancreatic Cancer Action. Retrieved 2017-11-20.
  4. ↑ Commisso, Cosimo; Davidson, Shawn M.; Soydaner-Azeloglu, Rengin G.; Parker, Seth J.; Kamphorst, Jurre J.; Hackett, Sean; Grabocka, Elda; Nofal, Michel; Drebin, Jeffrey A. (2013-05-12). "Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells". Nature. 497 (7451): 633–637. doi:10.1038/nature12138. ISSN 1476-4687. PMC 3810415. PMID 23665962.
  5. ↑ Kamphorst, Jurre J.; Nofal, Michel; Commisso, Cosimo; Hackett, Sean R.; Lu, Wenyun; Grabocka, Elda; Vander Heiden, Matthew G.; Miller, George; Drebin, Jeffrey A. (2015-02-01). "Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein". Cancer Research. 75 (3): 544–553. doi:10.1158/0008-5472.can-14-2211. PMC 4316379. PMID 25644265.
  6. ↑ Commisso, Cosimo; Flinn, Rory J; Bar-Sagi, Dafna (2014-01-02). "Determining the macropinocytic index of cells through a quantitative image-based assay". Nature Protocols. 9 (1): 182–192. doi:10.1038/nprot.2014.004. ISSN 1750-2799. PMC 4103788. PMID 24385148.
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