DeStefano is an Italian surname with Greek origin. People with the surname include:
- Cosmo P. DeStefano, American author
- Sam DeStefano, American gangster
- Mike DeStefano, American comedian
- Chris DeStefano, American singer
- Mario Anthony DeStefano, American gangster
- Lauren DeStefano, American author
- Anthony DeStefano, American author
- Frank DeStefano, medical researcher
- Joe DeStefano, politician
- Robert DeStefano, American chiropractor
- John DeStefano (disambiguation), several people
- Fred DeStefano, American football player
- Stephen DeStefano, American comics artist
See also
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