Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
Identifiers
EC no.2.4.1.261
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MetaCycmetabolic pathway
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Dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase (EC 2.4.1.261, ALG9, ALG9 alpha1,2 mannosyltransferase, dolichylphosphomannose-dependent ALG9 mannosyltransferase, ALG9 mannosyltransferase, Dol-P-Man:Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase) is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate

The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.

References

  1. ↑ Vleugels W, Keldermans L, Jaeken J, Butters TD, Michalski JC, Matthijs G, Foulquier F (August 2009). "Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient". Glycobiology. 19 (8): 910–7. doi:10.1093/glycob/cwp067. PMID 19451548.
  2. ↑ Frank CG, Aebi M (November 2005). "ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis". Glycobiology. 15 (11): 1156–63. doi:10.1093/glycob/cwj002. hdl:20.500.11850/31140. PMID 15987956.
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