EIF2C1

AGO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SI2, 1SI3, 4KRE, 4KRF, 4KXT
Identifiers
Aliases	AGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
External IDs	OMIM: 606228 MGI: 2446630 HomoloGene: 81826 GeneCards: AGO1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	35,930,532 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	126,362,376 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; visceral pleura; ; parietal pleura; ; hair follicle; ; monocyte; ; internal globus pallidus; ; tibia; ; stromal cell of endometrium; ; middle temporal gyrus; ; parotid gland;
	Top expressed in
	superior cervical ganglion; ; ganglionic eminence; ; vestibular labyrinth; ; ciliary body; ; otolith organ; ; iris; ; trigeminal ganglion; ; utricle; ; condyle; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II complex binding; miRNA binding; endoribonuclease activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; single-stranded RNA binding; RNA binding; nucleic acid binding; double-stranded RNA binding;
Cellular component	cytoplasm; polysome; cytosol; RISC complex; P-body; nucleoplasm; RISC-loading complex; nucleus; ribonucleoprotein complex;
Biological process	mRNA destabilization-mediated gene silencing by siRNA; regulation of transcription, DNA-templated; transcription, DNA-templated; pre-miRNA processing; nuclear-transcribed mRNA catabolic process; positive regulation of gene expression; RNA interference; miRNA-mediated gene silencing by inhibition of translation; RNA secondary structure unwinding; mRNA destabilization-mediated gene silencing by miRNA; miRNA metabolic process; regulation of translation; positive regulation of transcription by RNA polymerase II; production of miRNAs involved in gene silencing by miRNA; positive regulation of NIK/NF-kappaB signaling; Wnt signaling pathway, calcium modulating pathway; gene silencing; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; negative regulation of gene expression; negative regulation of angiogenesis; RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	26523
	236511
	ENSG00000092847
	ENSMUSG00000041530
	Q9UL18
	Q8CJG1
	NM_012199; NM_001317122; NM_001317123
	NM_153403; NM_001317173; NM_001317174; NM_001378879
	NP_001304051; NP_001304052; NP_036331
	NP_001304102; NP_001304103; NP_700452; NP_001365808
	Wikidata
View/Edit Human	View/Edit Mouse

Protein argonaute-1 is a protein that in humans is encoded by the EIF2C1 gene.^[5]^[6]^[7]

Function

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092847 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041530 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Oct 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406. S2CID 24461432.
↑ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Sep 2003). "Identification of eight members of the Argonaute family in the human genome". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
1 2 "Entrez Gene: EIF2C1 eukaryotic translation initiation factor 2C, 1".

Carmell MA, Xuan Z, Zhang MQ, Hannon GJ (Nov 2002). "The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis". Genes & Development. 16 (21): 2733–42. doi:10.1101/gad.1026102. PMID 12414724.
Reddy PH, Stockburger E, Gillevet P, Tagle DA (Dec 1997). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
Cikaluk DE, Tahbaz N, Hendricks LC, DiMattia GE, Hansen D, Pilgrim D, Hobman TC (Oct 1999). "GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation". Molecular Biology of the Cell. 10 (10): 3357–72. doi:10.1091/mbc.10.10.3357. PMC 25603. PMID 10512872.
Martinez J, Patkaniowska A, Urlaub H, Lührmann R, Tuschl T (Sep 2002). "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi". Cell. 110 (5): 563–74. doi:10.1016/S0092-8674(02)00908-X. hdl:11858/00-001M-0000-0012-F2FD-2. PMID 12230974. S2CID 10616773.
Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (Jan 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Current Biology. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. S2CID 14650075.
Ma JB, Ye K, Patel DJ (May 2004). "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain". Nature. 429 (6989): 318–22. Bibcode:2004Natur.429..318M. doi:10.1038/nature02519. PMC 4700412. PMID 15152257.
Sen GL, Blau HM (Jun 2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nature Cell Biology. 7 (6): 633–6. doi:10.1038/ncb1265. PMID 15908945. S2CID 6085169.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (Jul 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nature Cell Biology. 7 (7): 719–23. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
Chu CY, Rana TM (Jul 2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54". PLOS Biology. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
Kim DH, Villeneuve LM, Morris KV, Rossi JJ (Sep 2006). "Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells". Nature Structural & Molecular Biology. 13 (9): 793–7. doi:10.1038/nsmb1142. PMID 16936726. S2CID 26923711.
Janowski BA, Huffman KE, Schwartz JC, Ram R, Nordsell R, Shames DS, Minna JD, Corey DR (Sep 2006). "Involvement of AGO1 and AGO2 in mammalian transcriptional silencing". Nature Structural & Molecular Biology. 13 (9): 787–92. doi:10.1038/nsmb1140. PMID 16936728. S2CID 2230812.
Sasaki T, Shimizu N (Jul 2007). "Evolutionary conservation of a unique amino acid sequence in human DICER protein essential for binding to Argonaute family proteins". Gene. 396 (2): 312–20. doi:10.1016/j.gene.2007.04.001. PMID 17482383.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000092847 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041530 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10534406-5] Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Oct 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406. S2CID 24461432.

[pmid12906857-6] Sasaki T, Shiohama A, Minoshima S, Shimizu N (Sep 2003). "Identification of eight members of the Argonaute family in the human genome". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.

[entrez-7] 1 2 "Entrez Gene: EIF2C1 eukaryotic translation initiation factor 2C, 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Function

References

Further reading