EIF4EBP3
Identifiers
AliasesEIF4EBP3, 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDsOMIM: 603483 MGI: 1270847 HomoloGene: 37841 GeneCards: EIF4EBP3
Orthologs
SpeciesHumanMouse
Entrez

8637

108112

Ensembl

ENSG00000243056

ENSMUSG00000090264

UniProt

O60516

Q80VV3

RefSeq (mRNA)

NM_003732

NM_201256

RefSeq (protein)

NP_003723

NP_957708

Location (UCSC)Chr 5: 140.55 – 140.55 MbChr 18: 36.8 – 36.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.[5][6]

Function

This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.[6]

Interactions

EIF4EBP3 has been shown to interact with EIF4E.[5][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000243056 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090264 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. PMID 9593750.
  6. 1 2 "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
  7. Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

Further reading

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