ELL3

ELL3
Identifiers
Aliases	ELL3, ELL3 (gene), elongation factor for RNA polymerase II 3
External IDs	OMIM: 609885 MGI: 2673679 HomoloGene: 11859 GeneCards: ELL3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	43,777,315 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	121,274,759 bp
RNA expression pattern
	Top expressed in
	duodenum; ; lymph node; ; zone of skin; ; skin of abdomen; ; rectum; ; appendix; ; thymus; ; vagina; ; cerebellar hemisphere; ; minor salivary gland;
	Top expressed in
	spleen; ; morula; ; proximal tubule; ; kidney; ; zone of skin; ; yolk sac; ; blastocyst; ; secondary oocyte; ; respiratory epithelium; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleolus; transcription elongation factor complex; nucleus; nucleoplasm;
Biological process	positive regulation of DNA-templated transcription, elongation; positive regulation of neurogenesis; positive regulation of neural precursor cell proliferation; transcription elongation from RNA polymerase II promoter; regulation of epithelial to mesenchymal transition; DNA-templated transcription, elongation; regulation of transcription, DNA-templated; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; transcription by RNA polymerase II; spermatogenesis; positive regulation of transcription by RNA polymerase II; stem cell differentiation; transcription, DNA-templated; negative regulation of signal transduction by p53 class mediator; snRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	80237
	269344
	ENSG00000128886
	ENSMUSG00000027246
	Q9HB65
	Q80VR2
	NM_025165
	NM_145973
	NP_079441
	NP_666085
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor RNA polymerase II-like 3 is a protein that in humans is encoded by the ELL3 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128886 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027246 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Elongation factor RNA polymerase II-like 3".

Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C, Banks CA, Kong SE, Szutorisz H, Swanson SK, Martin-Brown S, Washburn MP, Florens L, Seidel CW, Lin C, Smith ER, Shilatifard A, Conaway RC, Conaway JW (July 2011). "Human mediator subunit MED26 functions as a docking site for transcription elongation factors". Cell. 146 (1): 92–104. doi:10.1016/j.cell.2011.06.005. PMC 3145325. PMID 21729782.
Park G, Gong Z, Chen J, Kim JE (April 2010). "Characterization of the DOT1L network: implications of diverse roles for DOT1L". The Protein Journal. 29 (3): 213–23. doi:10.1007/s10930-010-9242-8. PMID 20431927. S2CID 38143958.
Miller T, Williams K, Johnstone RW, Shilatifard A (October 2000). "Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3". The Journal of Biological Chemistry. 275 (41): 32052–6. doi:10.1074/jbc.M005175200. PMID 10882741.
Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (May 2009). "Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins". Proteomics. 9 (9): 2444–56. doi:10.1002/pmic.200800738. PMID 19343720. S2CID 22613066.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128886 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027246 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Elongation factor RNA polymerase II-like 3".

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References

Further reading