EXOC6
Identifiers
AliasesEXOC6, EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p, exocyst complex component 6
External IDsOMIM: 609672 MGI: 1351611 HomoloGene: 41305 GeneCards: EXOC6
Orthologs
SpeciesHumanMouse
Entrez

54536

107371

Ensembl

ENSG00000138190

ENSMUSG00000053799

UniProt

Q8TAG9

Q8R313

RefSeq (mRNA)

NM_001013848
NM_019053
NM_001319194
NM_001319195
NM_001319200

NM_175353

RefSeq (protein)

NP_001013870
NP_001306123
NP_001306124
NP_001306129
NP_061926

n/a

Location (UCSC)Chr 10: 92.83 – 93.06 MbChr 19: 37.51 – 37.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene.[5]

Function

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138190 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053799 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Exocyst complex component 6".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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