FBXO40
Identifiers
AliasesFBXO40, FBX40, F-box protein 40
External IDsOMIM: 609107 MGI: 2443753 HomoloGene: 9459 GeneCards: FBXO40
Orthologs
SpeciesHumanMouse
Entrez

51725

207215

Ensembl

ENSG00000163833

ENSMUSG00000047746

UniProt

Q9UH90

P62932

RefSeq (mRNA)

NM_016298

NM_001037321
NM_001358217

RefSeq (protein)

NP_057382

NP_001032398
NP_001345146

Location (UCSC)Chr 3: 121.59 – 121.63 MbChr 16: 36.78 – 36.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiquitination of IRS1, thus limiting activity of IGF1 signaling (Shi et al, 2011).[5][6]

Function

Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.[7]

Fbxo40 in particular engages a unique substrate, IRS1, which is a protein in the IGF1 signaling pathway. In this way, Fbxo40 causes ubiquitination and degradation of IRS1, blocking further signaling downstream of the IGF1 receptor.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163833 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047746 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ (November 2011). "The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling". Dev Cell. 21 (5): 835–47. doi:10.1016/j.devcel.2011.09.011. PMID 22033112.
  6. ↑ "Entrez Gene: F-box protein 40". Retrieved 2017-11-24.
  7. ↑ Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (November 2004). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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