FCRLA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCRLA, FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDsOMIM: 606891 MGI: 2138647 HomoloGene: 13106 GeneCards: FCRLA
Orthologs
SpeciesHumanMouse
Entrez

84824

98752

Ensembl

ENSG00000132185

ENSMUSG00000038421

UniProt

Q7L513

Q920A9

RefSeq (mRNA)

NM_001160215
NM_145141

RefSeq (protein)

NP_001153687
NP_660123

Location (UCSC)Chr 1: 161.71 – 161.71 MbChr 1: 170.75 – 170.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.[5][6]

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132185 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038421 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID 11754007. S2CID 196599868.
  6. 1 2 "Entrez Gene: FCRLA Fc receptor-like A".

Further reading


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