FRMPD4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFRMPD4, PDZD10, PDZK10, FERM and PDZ domain containing 4, MRX104
External IDsOMIM: 300838 MGI: 3042378 HomoloGene: 45843 GeneCards: FRMPD4
Orthologs
SpeciesHumanMouse
Entrez

9758

333605

Ensembl

ENSG00000169933

ENSMUSG00000049176

UniProt

Q14CM0

A2AFR3

RefSeq (mRNA)

NM_014728

RefSeq (protein)
Location (UCSC)Chr X: 12.14 – 12.72 MbChr X: 166.25 – 167.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene. [5]

Function

This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000169933 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049176 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FERM and PDZ domain containing 4". Retrieved 2016-10-01.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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