G3BP2

G3BP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DRV
Identifiers
Aliases	G3BP2, G3BP stress granule assembly factor 2
External IDs	MGI: 2442040 HomoloGene: 137244 GeneCards: G3BP2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	75,724,589 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,231,578 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; islet of Langerhans; ; Achilles tendon; ; frontal pole; ; pons; ; germinal epithelium; ; superior vestibular nucleus; ; prefrontal cortex; ; ganglionic eminence; ; Brodmann area 10;
	Top expressed in
	secondary oocyte; ; blood; ; anterior horn of spinal cord; ; nucleus accumbens; ; abdominal wall; ; facial motor nucleus; ; neural tube; ; ganglionic eminence; ; medial ganglionic eminence; ; ventral tegmental area;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor complex adaptor activity; protein binding; nucleic acid binding; mRNA binding; RNA binding;
Cellular component	intracellular anatomical structure; cytoplasm; cytosol; ribonucleoprotein complex; cytoplasmic stress granule;
Biological process	mRNA transport; Ras protein signal transduction; cytoplasmic sequestering of NF-kappaB; stress granule assembly; transport; positive regulation of signal transduction; viral process; protein homooligomerization; positive regulation of stress granule assembly; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	9908
	23881
	ENSG00000138757
	ENSMUSG00000029405
	Q9UN86
	P97379
	NM_012297; NM_203504; NM_203505
NM_001080794; NM_001080795; NM_001080796; NM_001080797; NM_011816;
	NM_001359195; NM_001359196; NM_001359197
	NP_036429; NP_987100; NP_987101; NP_987100.1
NP_001074263; NP_001074264; NP_001074265; NP_001074266; NP_035946;
	NP_001346124; NP_001346125; NP_001346126
	Wikidata
View/Edit Human	View/Edit Mouse

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene.^[5]^[6]^[7]

Interactions

G3BP2 has been shown to interact with IκBα.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138757 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029405 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS (June 1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif". Biomedical Peptides, Proteins & Nucleic Acids. 2 (3): 93–9. PMID 9575347.
↑ "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2".
↑ Prigent M, Barlat I, Langen H, Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". The Journal of Biological Chemistry. 275 (46): 36441–9. doi:10.1074/jbc.M004751200. PMID 10969074.

Kim MM, Wiederschain D, Kennedy D, Hansen E, Yuan ZM (June 2007). "Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP)". Oncogene. 26 (29): 4209–15. doi:10.1038/sj.onc.1210212. PMID 17297477. S2CID 20028334.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Prigent M, Barlat I, Langen H, Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". The Journal of Biological Chemistry. 275 (46): 36441–9. doi:10.1074/jbc.M004751200. PMID 10969074.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138757 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029405 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid9575347-6] Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS (June 1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif". Biomedical Peptides, Proteins & Nucleic Acids. 2 (3): 93–9. PMID 9575347.

[entrez-7] "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2".

[pmid10969074-8] Prigent M, Barlat I, Langen H, Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". The Journal of Biological Chemistry. 275 (46): 36441–9. doi:10.1074/jbc.M004751200. PMID 10969074.

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Interactions

References

Further reading