G6PC2
Identifiers
AliasesG6PC2, IGRP, glucose-6-phosphatase catalytic subunit 2
External IDsOMIM: 608058 MGI: 1277193 HomoloGene: 41423 GeneCards: G6PC2
Orthologs
SpeciesHumanMouse
Entrez

57818

14378

Ensembl

ENSG00000278373
ENSG00000152254

ENSMUSG00000005232

UniProt

Q9NQR9

Q9Z186

RefSeq (mRNA)

NM_001081686
NM_021176

NM_001289856
NM_001289857
NM_021331

RefSeq (protein)

NP_001075155
NP_066999

NP_001276785
NP_001276786
NP_067306

Location (UCSC)Chr 2: 168.9 – 168.91 MbChr 2: 69.04 – 69.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucose-6-phosphatase 2 is an enzyme that in humans is encoded by the G6PC2 gene.[5][6][7]

Function

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.[7]

References

  1. 1 2 3 ENSG00000152254 GRCh38: Ensembl release 89: ENSG00000278373, ENSG00000152254 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005232 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC (Mar 1999). "Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein". Diabetes. 48 (3): 531–42. doi:10.2337/diabetes.48.3.531. PMID 10078553.
  6. Ebert DH, Bischof LJ, Streeper RS, Chapman SC, Svitek CA, Goldman JK, Mathews CE, Leiter EH, Hutton JC, O'Brien RM (Mar 1999). "Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene". Diabetes. 48 (3): 543–51. doi:10.2337/diabetes.48.3.543. PMID 10078554.
  7. 1 2 "Entrez Gene: G6PC2 glucose-6-phosphatase, catalytic, 2".

Further reading


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