GAS6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGAS6, AXLLG, AXSF, growth arrest specific 6
External IDsOMIM: 600441 MGI: 95660 HomoloGene: 638 GeneCards: GAS6
Orthologs
SpeciesHumanMouse
Entrez

2621

14456

Ensembl

ENSG00000183087

ENSMUSG00000031451

UniProt

Q14393

Q61592

RefSeq (mRNA)

NM_001143946
NM_000820
NM_001143945

NM_019521

RefSeq (protein)

NP_000811

NP_062394

Location (UCSC)Chr 13: 113.82 – 113.86 MbChr 8: 13.52 – 13.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

Function

Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.[5]

Interactions

Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3.[6][7]

The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum. The action of vitamin K is essential on GAS6 function.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183087 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031451 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GAS6 growth arrest-specific 6".
  6. Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (Apr 1996). "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl". J. Biol. Chem. 271 (16): 9785–9. doi:10.1074/jbc.271.16.9785. PMID 8621659.
  7. Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (Nov 1996). "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases". J. Biol. Chem. 271 (47): 30022–7. doi:10.1074/jbc.271.47.30022. PMID 8939948.
  8. Bellido-Martín, L; de Frutos, PG (2008). "Vitamin K-dependent actions of Gas6". Vitamins and Hormones. 78: 185–209. doi:10.1016/S0083-6729(07)00009-X. hdl:10261/37140. ISBN 9780123741134. PMID 18374195.

Further reading


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