GCLC
Identifiers
AliasesGCLC, GCL, GCS, GLCL, GLCLC, glutamate-cysteine ligase catalytic subunit
External IDsOMIM: 606857 MGI: 104990 HomoloGene: 1148 GeneCards: GCLC
Orthologs
SpeciesHumanMouse
Entrez

2729

14629

Ensembl

ENSG00000001084

ENSMUSG00000032350

UniProt

P48506

P97494

RefSeq (mRNA)

NM_001498
NM_001197115

NM_010295

RefSeq (protein)

NP_001184044
NP_001489

NP_034425

Location (UCSC)Chr 6: 53.5 – 53.62 MbChr 9: 77.66 – 77.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate—cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene.[5][6]

Function

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000001084 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032350 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gipp JJ, Chang C, Mulcahy RT (May 1992). "Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase". Biochemical and Biophysical Research Communications. 185 (1): 29–35. doi:10.1016/S0006-291X(05)80950-7. PMID 1350904.
  6. 1 2 "Entrez Gene: GCLC glutamate-cysteine ligase, catalytic subunit".

Further reading

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