GCLM
Identifiers
AliasesGCLM, GLCLR, glutamate-cysteine ligase modifier subunit
External IDsOMIM: 601176 MGI: 104995 HomoloGene: 1557 GeneCards: GCLM
Orthologs
SpeciesHumanMouse
Entrez

2730

14630

Ensembl

ENSG00000023909

ENSMUSG00000028124

UniProt

P48507

O09172

RefSeq (mRNA)

NM_001308253
NM_002061

NM_008129

RefSeq (protein)

NP_001295182
NP_002052

NP_032155

Location (UCSC)Chr 1: 93.89 – 93.91 MbChr 3: 122.04 – 122.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.[5][6]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000023909 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028124 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gipp JJ, Bailey HH, Mulcahy RT (Feb 1995). "Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues". Biochem Biophys Res Commun. 206 (2): 584–9. doi:10.1006/bbrc.1995.1083. PMID 7826375.
  6. 1 2 "Entrez Gene: GCLM glutamate-cysteine ligase, modifier subunit".

Further reading


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