GFPT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGFPT1, CMSTA1, GFA, GFAT, GFAT 1, GFAT1, GFAT1m, GFPT, GFPT1L, MSLG, CMS12, glutamine--fructose-6-phosphate transaminase 1
External IDsOMIM: 138292 MGI: 95698 HomoloGene: 68220 GeneCards: GFPT1
Orthologs
SpeciesHumanMouse
Entrez

2673

14583

Ensembl

ENSG00000198380

ENSMUSG00000029992

UniProt

Q06210

P47856

RefSeq (mRNA)

NM_002056
NM_001244710

NM_013528

RefSeq (protein)

NP_001231639
NP_002047

NP_038556

Location (UCSC)Chr 2: 69.32 – 69.39 MbChr 6: 87.02 – 87.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glucosamine—fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene.[5][6]

Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198380 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029992 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McKnight GL, Mudri SL, Mathewes SL, Traxinger RR, Marshall S, Sheppard PO, O'Hara PJ (Jan 1993). "Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase". J Biol Chem. 267 (35): 25208–12. doi:10.1016/S0021-9258(19)74026-5. PMID 1460020.
  6. 1 2 "Entrez Gene: GFPT1 glutamine-fructose-6-phosphate transaminase 1".

Further reading


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