CGA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA, Chorionic gonadotropin alpha, glycoprotein hormones, alpha polypeptide, Alpha subunit of glycoprotein hormones, GPA1
External IDsOMIM: 118850 MGI: 88390 HomoloGene: 587 GeneCards: CGA
Orthologs
SpeciesHumanMouse
Entrez

1081

12640

Ensembl

ENSG00000135346

ENSMUSG00000028298

UniProt

P01215

P01216

RefSeq (mRNA)

NM_001252383
NM_000735

NM_009889

RefSeq (protein)

NP_000726
NP_001239312

NP_034019

Location (UCSC)Chr 6: 87.09 – 87.1 MbChr 4: 34.89 – 34.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene.[5]

The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein hormones are identical; however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135346 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028298 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fiddes JC, Goodman HM (Oct 1982). "The gene encoding the common alpha subunit of the four human glycoprotein hormones". Journal of Molecular and Applied Genetics. 1 (1): 3–18. PMID 6286817.
  6. "Entrez Gene: CGA glycoprotein hormones, alpha polypeptide".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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