H2AC7
Identifiers
AliasesH2AC7, H2A.3, H2A/g, H2AFG, histone cluster 1, H2ad, histone cluster 1 H2A family member d, H2A clustered histone 7, HIST1H2AD
External IDsOMIM: 602792 MGI: 2448306 HomoloGene: 137350 GeneCards: H2AC7
Orthologs
SpeciesHumanMouse
Entrez

3013

319172

Ensembl

ENSG00000196866

ENSMUSG00000061615

UniProt

P20671

RefSeq (mRNA)

NM_021065

NM_175660

RefSeq (protein)

NP_066409

Location (UCSC)Chr 6: 26.2 – 26.2 MbChr 13: 23.94 – 23.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 1-D is a protein that in humans is encoded by the HIST1H2AD gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196866 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061615 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. 1 2 "Entrez Gene: HIST1H2AD histone cluster 1, H2ad".

Further reading


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