Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B58
Alleles *5801, *5802
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57.[1] The serotype identifies the more common HLA-B*58 gene products.[2] (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.

Serotype

B58 and B17 serotype recognition of some more common HLA B*58 alleles[3]
B*58B58 B17Sample
allele % %size (N)
*58017942096
*5802723837

Allele distribution

HLA B*5801 frequencies
freq
ref.Population(%)
[4]Cameroon Pygmy Baka15.0
[4]India Khandesh Pawra15.0
[4]Cameroon Sawa11.5
[4]Taiwan Hakka10.9
[4]Kenya Nandi10.0
[4]India West Bhils9.0
[4]China South Han8.9
[4]China Inner Mongolia8.8
[4]India North Delhi8.8
[4]Thailand Northeast8.4
[4]Guinea Bissau7.8
[4]Thailand7.7
[4]India Mumbai Marathas7.4
[4]India Andhra Pradesh Golla7.2
[4]Kenya Luo7.0
[4]Senegal Niokholo Mandenka6.9
[4]India New Delhi6.8
[4]Oman6.8
[4]Russia Tuva (2)6.7
[4]South Korea (3)6.5
[4]Italy Sardinia (3)6.4
[4]Burkina Faso Fulani6.1
[4]Taiwan Siraya5.9
[4]India North Hindus5.8
[4]Burkina Faso Mossi5.7
[4]Cameroon Yaounde5.4
[4]Cameroon Bamileke5.2
[4]Singapore Riau Malay5.0
[4]Saudi Arabia Guraiat and Hail4.6
[4]France Corsica4.5
[4]Sudanese4.5
[4]Zimbabwe Harare Shona4.4
[4]Burkina Faso Rimaibe4.3
[4]Iran Baloch4.0
[4]South African Natal Zulu4.0
[4]Tunisia4.0
[4]Uganda Kampala4.0
[4]Cameroon Beti3.7
[4]Tunisia Ghannouch3.7
[4]Taiwan Pazeh3.6
[4]Tunisia Tunis3.4
[4]Italy North (1)3.3
[4]Israel Ashkenazi and Non Ashkenazi Jews3.2
[4]India West Coast Parsis3.0
[4]China North Han2.9
[4]Ivory Coast Akan Adiopodoume2.3
[4]Mali Bandiagara2.2
[4]Mexico Zaptotec Oaxaca2.2
[4]South Africa Natal Tamil2.0
[4]China Yunnan Nu1.9
[4]Bulgaria1.8
[4]China Tibet Autonomous Region Tibetans1.6
[4]France South East1.6
[4]Israel Arab Druse1.5
[4]Czech Republic1.4
[4]Georgia Tbilisi Georgians1.4
[4]Jordan Amman1.4
[4]Morocco Nador Metalsa (berber)1.4
[4]Croatia1.3
[4]Romanian1.3
[4]Spain Eastern Andalusia1.2
[4]Australian Aborigine Cape York Peninsula1.0
B*5802
[4]Cameroon Bamileke14.3
[4]Kenya Luo12.5
[4]Cameroon Yaounde10.9
[4]Cameroon Pygmy Baka10.0
[4]Cameroon Beti9.8
[4]Kenya Nandi8.5
[4]South African Natal Zulu8.5
[4]Cameroon Sawa7.7
[4]Zimbabwe Harare Shona6.4
[4]Cape Verde Northwestern Islands5.6
[4]Uganda Kampala4.4
[4]Central Africa Republic Mbenzele Pygmy4.0
[4]Zambia Lusaka2.3
[4]Iran Baloch1.0
[4]Tunisia1.0

Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome.[5][6] Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN).[7] The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.[8]

References

  1. ↑ Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem. 260 (22): 11924–33. doi:10.1016/S0021-9258(17)38967-6. PMID 2995352.
  2. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  3. ↑ derived from IMGT/HLA
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)
  5. ↑ Chung WH, Hung SI, Chen YT (August 2007). "Human leukocyte antigens and drug hypersensitivity". Curr Opin Allergy Clin Immunol. 7 (4): 317–23. doi:10.1097/ACI.0b013e3282370c5f. PMID 17620823. S2CID 31415054.
  6. ↑ Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W (2009). "Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population". Pharmacogenet Genomics. 19 (9): 704–9. doi:10.1097/FPC.0b013e328330a3b8. PMID 19696695. S2CID 24941838.
  7. ↑ Hung SI, Chung WH, Liou LB, et al. (March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proc. Natl. Acad. Sci. U.S.A. 102 (11): 4134–9. Bibcode:2005PNAS..102.4134H. doi:10.1073/pnas.0409500102. PMC 554812. PMID 15743917.
  8. ↑ Lonjou C, Borot N, Sekula P, et al. (February 2008). "A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs". Pharmacogenet. Genomics. 18 (2): 99–107. doi:10.1097/FPC.0b013e3282f3ef9c. PMID 18192896. S2CID 35512622.
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