Hanadi Sleiman

FRS
Born
Hanadi Farouk Sleiman
Alma materStanford University
Scientific career
InstitutionsMcGill University
French National Centre for Scientific Research
Thesis"Photochemical" azo metathesis by tungsten carbenes. Generation of low valent tungsten nitrenes (1990)
Academic advisorsJean-Marie Lehn

Hanadi Farouk Sleiman FRS is a Canadian chemist who is Canada Research Chair in DNA Nanoscience at McGill University. Her research makes use of DNA as a template for nanomaterials. She was awarded the Natural Sciences and Engineering Research Council Polanyi Award in 2021.

Early life and education

Sleiman was an undergraduate and doctoral researcher at Stanford University, where she studied tungsten nitrenes. At Stanford, she attended a lecture by Jean-Marie Lehn who discussed supramolecular chemistry. After earning her doctorate, she moved to the Louis Pasteur University as a French National Centre for Scientific Research (CNRS) Fellow, where she worked alongside Jean-Marie Lehn.

Research and career

In 1999, Sleiman joined the faculty at McGill University, where she started using DNA to assemble nanomaterials. In particular she is interested in DNA structures that can target cancer cells and make them respond to chemotherapy.[1] She has designed tuneable DNA cages and nanotubes that can encapsulate and selectively release pharmaceuticals when they encounter a biological stimulus.[2] These non toxic cages can facilitate personalised drug delivery, that is, healthcare that is based on a person's genetics, environment or lifestyle.[3] They can rapidly enter mammalian cells, turning on and off gene expression and modulating their behaviour.[2] Sleiman has proposed that nucleic acids will enable precision oncology.[4][5]

Sleiman has shown that it is possible to chemically imprint polymer particles with DNA strands for soft robotics.[6] She joined the Society for the Advancement of Science and Technology in the Arab World in 2011.[7]

Awards and honours

Selected publications

  • F. A. Aldaye; A. L. Palmer; H. F. Sleiman (26 September 2008). "Assembling Materials with DNA as the Guide". Science. 321 (5897): 1795–1799. doi:10.1126/SCIENCE.1154533. ISSN 0036-8075. PMID 18818351. Wikidata Q22065862.
  • Faisal A Aldaye; Hanadi F Sleiman (16 October 2007). "Modular access to structurally switchable 3D discrete DNA assemblies". Journal of the American Chemical Society. 129 (44): 13376–13377. doi:10.1021/JA075966Q. ISSN 0002-7863. PMID 17939666. Wikidata Q34583813.
  • Pik Kwan Lo; Pierre Karam; Faisal A Aldaye; Christopher K McLaughlin; Graham D Hamblin; Gonzalo Cosa; Hanadi F Sleiman (14 March 2010). "Loading and selective release of cargo in DNA nanotubes with longitudinal variation". Nature Chemistry. 2 (4): 319–328. doi:10.1038/NCHEM.575. ISSN 1755-4330. PMID 21124515. Wikidata Q34625544.

References

  1. ↑ Interview with Hanadi Sleiman, retrieved 2023-03-03
  2. 1 2 "DNA Nanostructures for Cellular Delivery of TherapeuticsDr. Hanadi Sleiman (McGill) – Concordia University". www.concordia.ca. Retrieved 2023-03-03.
  3. 1 2 "McGill's Hanadi Sleiman wins 2021 Polanyi Award". McGill Institute for Advanced Materials. Retrieved 2023-03-03.
  4. ↑ Thurston, Meaghan (2022-09-21). "CFI invests $3.9 M in McGill research". McGill Reporter. Retrieved 2023-03-03.
  5. ↑ Fernando Gomollón-Bel2016-10-21T12:28:00+01:00. "DNA suitcases packed with gene therapy cargo". Chemistry World. Retrieved 2023-03-03.{{cite web}}: CS1 maint: numeric names: authors list (link)
  6. ↑ "Using DNA strands to design new polymer materials". Newsroom. Retrieved 2023-03-03.
  7. ↑ "SASTA". Retrieved 2023-03-03.
  8. ↑ old_old (2008-11-13). "From fiddles to inorganic chemistry". McGill Reporter. Retrieved 2023-03-03.
  9. ↑ "Prof. H. Sleiman, winner of the Canadian Society for Chemistry's 2009 Strem Chemicals Award for Pure or Applied Inorganic Chemistry". Channels. Retrieved 2023-03-03.
  10. ↑ "Swiss Chemical Society – Lectures". scg.ch. Retrieved 2023-03-03.
  11. ↑ "ISMSC Awards | Chemistry". www.chem.byu.edu. Retrieved 2023-03-03.
  12. ↑ "Netherlands Scholar Award for Supramolecular Chemistry for Prof. Hanadi Sleiman – FMS Research Center". fmsresearch.nl. Retrieved 2023-03-03.
  13. ↑ "Hanadi Sleiman – Killam Research Fellow". Killam Laureates. Retrieved 2023-03-03.
  14. ↑ "Hanadi Sleiman". Department of Chemistry. Retrieved 2023-03-03.
  15. ↑ Advancement, Research Corporation for Science. "2021 Cottrell IMPACT and STAR Awards Announced". Research Corporation for Science Advancement. Retrieved 2023-03-03.
  16. ↑ "2022 BMS Lecture, Presented by Prof. Hanadi Sleiman | Chemistry". www.chem.columbia.edu. Retrieved 2023-03-03.
  17. ↑ "Exceptional scientists elected as Fellows of the Royal Society". The Royal Society. May 10, 2023. Retrieved May 10, 2023.
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