Hypothalamic obesity (abbreviated HO or HyOb) is a rare condition that can be congenital or acquired. Congenital causes include Prader-Willi syndrome and mutations of LEP (leptin gene), LEPR, POMC, MC4R, and CART. It can also result from injuries to the hypothalamus either from trauma, therapeutic radiation, brain surgery, and especially craniopharyngioma and its treatments. Possible treatments include bariatric surgery and melanocortin 4 receptor agonists such as setmelanotide.[1][2][3][4]

References

  1. ↑ Dimitri, Paul (6 April 2022). "Treatment of Acquired Hypothalamic Obesity: Now and the Future". Frontiers in Endocrinology. 13: 846880. doi:10.3389/fendo.2022.846880. ISSN 1664-2392. PMC 9019363. PMID 35464063.
  2. ↑ Bereket, A.; Kiess, W.; Lustig, R. H.; Muller, H. L.; Goldstone, A. P.; Weiss, R.; Yavuz, Y.; Hochberg, Z. (September 2012). "Hypothalamic obesity in children". Obesity Reviews. 13 (9): 780–798. doi:10.1111/j.1467-789X.2012.01004.x. PMID 22577758. S2CID 9550333.
  3. ↑ Abuzzahab, M. Jennifer; Roth, Christian L.; Shoemaker, Ashley H. (2019). "Hypothalamic Obesity: Prologue and Promise". Hormone Research in Paediatrics. 91 (2): 128–136. doi:10.1159/000496564. PMID 30884480. S2CID 83460590.
  4. ↑ Kim, Ja Hye; Choi, Jin-Ho (December 2013). "Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents". Annals of Pediatric Endocrinology & Metabolism. 18 (4): 161–167. doi:10.6065/apem.2013.18.4.161. ISSN 2287-1012. PMC 4027083. PMID 24904871.
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