ICMT
Identifiers
AliasesICMT, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT, isoprenylcysteine carboxyl methyltransferase, ICMT protein, human
External IDsOMIM: 605851 MGI: 1888594 HomoloGene: 5735 GeneCards: ICMT
Orthologs
SpeciesHumanMouse
Entrez

23463

57295

Ensembl

ENSG00000116237

ENSMUSG00000039662

UniProt

O60725

Q9EQK7

RefSeq (mRNA)

NM_012405
NM_170705

NM_133788

RefSeq (protein)

NP_036537

NP_598549

Location (UCSC)Chr 1: 6.22 – 6.24 MbChr 4: 152.3 – 152.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.[5][6][7]

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116237 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039662 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR (Jul 1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum". J Biol Chem. 273 (24): 15030–4. doi:10.1074/jbc.273.24.15030. PMID 9614111.
  6. Desrosiers RR, Nguyen QT, Beliveau R (Sep 1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem Biophys Res Commun. 261 (3): 790–7. doi:10.1006/bbrc.1999.0936. PMID 10441503.
  7. 1 2 "Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase".

Further reading


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