Imjin thottimvirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Thottimvirus
Species:
Imjin thottimvirus
Synonyms[1]
  • Imjin orthohantavirus

Imjin thottimvirus (MJNV) is a single-stranded, enveloped, negative-sense RNA virus of the orthohantavirus genus in the Bunyavirales order. It is a newly identified hantavirus isolated from the lung tissues of Ussuri white-toothed shrews of the species Crocidura lasiura (order Soricomorpha, family Soricidae, subfamily Crocidurinae) captured near the demilitarized zone in the Republic of Korea during 2004 and 2005.

Virology

Phylogenetic analyses demonstrates a common ancestry with Thottopalayam thottimvirus suggesting early evolutionary divergence. It is still unknown if MJNV is pathogenic for humans.[2]

MJNV has been shown to be a genetically unique hantavirus. Multiple strains have been isolated from the lung tissues of Ussuri white-toothed shrews captured between 2004 and 2010. Partial M- and L-segment sequences from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive shrews revealed that the 12 MJNV strains differed by 0–12.2% and 0–2.3% at the nucleotide and amino acid levels. A similar degree of nucleotide and amino acid difference was found in a 632-nucleotide length of the L segment of nine MJNV strains. Phylogenetic analyses demonstrated a geographic relationship similar to the phylogeography of rodent-borne hantaviruses.[3]

See also

References

  1. ↑ Briese, Thomas. "In the genus Hantavirus (proposed family Hantaviridae, proposed order Bunyavirales), create 24 new species, abolish 7 species, change the demarcation criteria, and change the name of the genus to Orthohantavirus; likewise, rename its constituent species" (PDF). International Committee on Taxonomy of Viruses (ICTV). Retrieved 4 March 2019.
  2. ↑ Song, JW; Kang, HJ; Gu, SH; Moon, SS; Bennett, SN; Song, KJ; Baek, LJ; Kim, HC; O'Guinn, ML; Chong, ST; Klein, TA; Yanagihara, R (Jun 2009). "Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura)". J Virol. 83 (12): 6184–91. doi:10.1128/JVI.00371-09. PMC 2687366. PMID 19357167.
  3. ↑ Gu, SH; Kang, HJ; Baek, LJ; Noh, JY; Kim, HC; Klein, TA; Yanagihara, R; Song, JW (2011). "Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004–2010". Virol J. 8: 56. doi:10.1186/1743-422X-8-56. PMC 3046926. PMID 21303516.
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