Immunoglobulin C1-set domain
Structure of T-cell surface glycoprotein CD1d antigen.[1]
Identifiers
SymbolC1-set
PfamPF07654
InterProIPR003597
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

C1-set domains are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules,[2][3] and in various T-cell receptors.

Human proteins containing this domain

AZGP1; B2M; CD1A; CD1B; CD1C; CD1D; CD1E; DMA; DQB2; DRB1; ELK2P1; FCGRT; HFE; HHLA2; HLA-A; HLA-B; HLA-B35; HLA-B57; HLA-C; HLA-CW; HLA-Cw; HLA-D; HLA-DMA; HLA-DMB; HLA-DOA; HLA-DOB; HLA-DP; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB2; HLA-DRB3; HLA-DRB4; HLA-DRw12; HLA-Dw12; HLA-E; HLA-F; HLA-G; HLA-G2.2; HLA-H; HLAC; IGHA1; IGHA2; IGHD; IGHE; IGHG1; IGHG2; IGHG3; IGHG4; IGHM; IGHV4-31; IGKC; IGKV1-5; IGKV2-24; IGL@; IGLC1; IGLC3; IGLL1; IGLV2-14; IGLV3-21; IGLV3-25; IGLV4-3; MICA; MICB; MR1; SIRPA; SIRPB1; SIRPG; SNC73; TAPBP; TAPBPL; TRBC1; TRBV19; TRBV21-1; TRBV3-1; TRBV5-4; TRBV7-2; micB;

References

  1. ↑ Zajonc DM, Cantu C, Mattner J, et al. (August 2005). "Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor". Nat. Immunol. 6 (8): 810–8. doi:10.1038/ni1224. PMC 2045075. PMID 16007091.
  2. ↑ Cresswell P, Pamer E (1998). "Mechanisms of MHC class I--restricted antigen processing". Annu. Rev. Immunol. 16 (1): 323–358. doi:10.1146/annurev.immunol.16.1.323. PMID 9597133.
  3. ↑ Ono SJ, Radosevich M (2003). "Novel mechanisms of class II major histocompatibility complex gene regulation". Immunol Res. 27 (1): 85–106. doi:10.1385/IR:27:1:85. PMID 12637770. S2CID 5872652.
This article incorporates text from the public domain Pfam and InterPro: IPR003597
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