Jacqueline A. Lees
Alma materUniversity of York
University of London
Scientific career
FieldsBiochemistry, cancer biology
InstitutionsKoch Institute for Integrative Cancer Research, MIT

Jacqueline A. Lees is a British biochemist.

Lees is the Virginia and D.K. Ludwig Professor for Cancer Research and associate director of the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology.[1] She received her BSc degree from the University of York in 1986, and her PhD from the University of London in 1990, both in biochemistry.[2] She was a postdoc in the laboratory of Ed Harlow, first at Cold Spring Harbor and then at Massachusetts General Hospital, before joining the faculty at MIT in 1994.[3]

Research

Lees’ research is focused on identifying the proteins and pathways that play a key role in tumorigenicity and establishing the mechanism of their action in both normal and tumor cells.[1] Her lab at MIT uses a combination of molecular and cellular analyses and mutant mouse models. She is also known for her work with Nancy Hopkins on genetic screens in zebrafish.[4] Lees studies how the E2F family of mammalian transcription factors contributes to the regulation of cellular proliferation during normal development and tumorigenesis.[1] Her work has shown that certain E2Fs, despite substantial biochemical similarities, play radically different biological roles.[5]

References

  1. 1 2 3 "The Koch Institute: Jacqueline A. Lees". ki.mit.edu. Retrieved 2020-05-18.
  2. ↑ "Corporation awards tenure to 23 faculty members". MIT News. 17 October 2001. Retrieved 2020-05-18.
  3. ↑ "Sizer CD Chair is established". MIT News. May 1996. Retrieved 2020-05-18.
  4. ↑ Zhang, GuangJun; Hoersch, Sebastian; Amsterdam, Adam; Whittaker, Charles A.; Lees, Jacqueline A.; Hopkins, Nancy (2010-09-28). "Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers". Proceedings of the National Academy of Sciences. 107 (39): 16940–16945. Bibcode:2010PNAS..10716940Z. doi:10.1073/pnas.1011548107. ISSN 0027-8424. PMC 2947874. PMID 20837522.
  5. ↑ Iaquinta, Phillip J; Lees, Jacqueline A (2007-12-01). "Life and death decisions by the E2F transcription factors". Current Opinion in Cell Biology. Cell differentiation / Cell division, growth and death. 19 (6): 649–657. doi:10.1016/j.ceb.2007.10.006. ISSN 0955-0674. PMC 2268988. PMID 18032011.
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