James Bumgardner Murphy (4 August 1884 – 24 August 1950) was an American physiologist and anatomist who developed techniques for growing chicken and human tumor cells in fertilized chicken eggs which is used in cancer studies as well as for maintaining virus cultures. He also recognized the role of the immune system, particularly lymphocytes, in the rejection of tissue grafts.[1]

Murphy was born in Morgantown, North Carolina where his father psychiatrist Dr Patrick Livingston Murphy was director of the Western State Sanatorium. He grew up in Morgantown where he went to Horner School before graduating from the University of North Carolina. He then joined Johns Hopkins Medical School in 1905 where he excelled in anatomical dissection and illustration, which impressed Harvey Cushing. He then worked as an assistant to Adolph Meyer and later joined the Rockefeller Institute to work under Peyton Rous in 1911. He developed techniques for growing mammalian tumor cells in embryonated hen's eggs. During World War I, Murphy worked in Washington with Hans Zinsser to organize mobile hospitals and helped develop an Army Medical Laboratory Manual. An ulcer, and a surgery with complications led to several years of poor health and convalescence. He became a director of cancer research at the Rockefeller Institute, working there until his death.[2][3][4]

References

  1. ↑ Murphy, James Bumgardner (1926). The Lymphocyte in Resistance to Tissue Grafting, Malignant Disease, and Tuberculous Infection: An Experimental Study. No. 21. Rockefeller Institute for Medical Research.
  2. ↑ Little, C.C. (1960). "James Bumgardner Murphy 1884—1950. A biographical memoir" (PDF). Biographical Memoirs of the National Academy of Sciences.
  3. ↑ Löwy, I. (1989). "Biomedical research and the constraints of medical practice: James Bumgardner Murphy and the early discovery of the role of lymphocytes in immune reactions". Bulletin of the History of Medicine. 63 (3): 356–391. PMID 2686778.
  4. ↑ Longcope, W.T. (1951). "James Bumgardner Murphy, 1884-1950". Transactions of the Association of American Physicians. 64: 15–18. PMID 14884225.
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