1984–99: Beginnings and Clueless

Sisto made his film debut in the 1991 drama Grand Canyon, starring Kevin Kline and Steve Martin. He followed this with roles in the television films Desperate Choices: To Save My Child (1992) and The Shaggy Dog (1994). In his early film and television career, Sisto played a killer in Hideaway (1995); a rich teen in Clueless (1995); a 20-something kidnapper in Suicide Kings (1997); Olympic gold medalist long-distance runner Frank Shorter in Without Limits (1998); Jesus Christ in the CBS miniseries Jesus (1999); and a widowed filmmaker in This Space Between Us (1999). He has also starred in the films Moonlight and Valentino (1995), White Squall (1996), Bongwater (1997), Some Girl (1998), and Playing by Heart (1998). In 1996, Sisto screen tested for the character of Jack Dawson in the James Cameron film Titanic alongside Kate Winslet but ultimately lost out on the role to Leonardo DiCaprio.^[6] In 1998, he portrayed Frederick W. Seward in the TNT television film The Day Lincoln Was Shot.^[7]

2000–10: Six Feet Under and Law & Order

From 2001 to 2005, he portrayed Billy Chenowith in the HBO drama series Six Feet Under. For that work, he was twice nominated for the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series along with his co-stars.^[8] Sisto starred in the 2001 drama film Angel Eyes, alongside Jennifer Lopez. In 2003, Sisto starred in the drama film Thirteen, the romantic comedy The Movie Hero, and the horror film Wrong Turn. That same year, he also appeared in the series finale of The WB's teen drama series Dawson's Creek.^[9] Sisto then performed on the Los Angeles stage, playing the role of bigoted Southerner Shane Mungitt in Richard Greenberg's play Take Me Out, about a baseball player who announces he is gay;^[10] Sisto was nominated for a Los Angeles Drama Critics Circle Award for his role.^[11]

In 2006, he appeared in the Broadway play Festen at the Music Box Theatre.^[12] In the same year, he starred in the short-lived NBC drama series Kidnapped,^[13] top-lined the direct-to-video mystery horror film Population 436, and starred in the crime-thriller film Unknown. In July 2007, Sisto was featured in the Maroon 5 video for the song "Wake Up Call". He played a man who was sleeping with the girlfriend of Adam Levine.^[14] That same year, he appeared as Earl Hunterson opposite Keri Russell in the comedy-drama film Waitress.^[15]

In 2008, Sisto joined the cast of the NBC crime drama series Law & Order, as Detective Cyrus Lupo, replacing Milena Govich's Detective Nina Cassady as the partner of Jesse L. Martin's Ed Green.^[16] Sisto had already appeared on the show, as a lawyer, in the previous season's finale. Sisto stayed on for the series' next three seasons, and his character became partners with Anthony Anderson's Detective Kevin Bernard after Martin left the series near the end of season 18. Also in 2008, Sisto starred in the drama film Gardens of the Night, and voiced the role of Batman in the direct-to-video film Justice League: The New Frontier.^[17] In 2009, he played a Catholic priest, alongside Kristin Chenoweth as a prostitute, in the independent drama film Into Temptation.^[18] The following year, he starred in the Manhattan Theatre Club production of Spirit Control at the New York City Center, gaining rave reviews for his performance as Adam Wyatt.^[19]

2011–present: Suburgatory, screenwriting debut and FBI

From 2011 to 2014, Sisto starred in the ABC comedy series Suburgatory, which premiered on September 28, 2011.^[20] He played the role of George Altman, the divorced father of the series' main character, for three seasons, after which the series was cancelled.^[21][22] Sisto was nominated for the 2013 Critics' Choice Television Award for Best Actor in a Comedy Series for his performance as George. In 2011, he starred in the drama film Sironia, directed by Brandon Dickerson. In 2012, he starred as Sheriff Rowlings in the critically acclaimed science-fiction comedy-drama Robot & Frank.^[23] The following year, Sisto co-starred as Guy Karlsburg, alongside James Marsden and Claire Danes, in the comedy-drama As Cool as I Am.

In 2014, Sisto co-wrote the screenplay for the comedy film Break Point with Gene Hong. He also starred in the film and served as a producer.^[24] On June 5, 2014, it was announced that Sisto had joined the cast of Carlton Cuse's remake of The Returned for the cable channel A&E.^[25] The series lasted one season before it was cancelled by the network.^[26] He then voiced Talon in the animated direct-to-video film Batman vs. Robin.^[27] In 2015, Sisto produced and starred as Aaron Miller in the British thriller film Hangman, which had its premiere at South by Southwest.^[28] That same year, he joined the cast of ABC's crime drama series Wicked City. Sisto portrayed Detective Jack Roth, an LAPD officer searching for a serial killer on the Sunset Strip. The role was originally portrayed by Adam Rothenberg, but after the series was given its premiere date, the role was recast.^[29] It was poorly received by critics and was cancelled by ABC after airing only three episodes following weak ratings.

Sisto was then cast alongside Archie Panjabi in ABC's drama pilot The Jury, but the project was not picked up to series.^[30] From 2016–2018, Sisto starred as Freddy Green in Antoine Fuqua's Audience Network drama series Ice, opposite Cam Gigandet and Donald Sutherland.^[31] Sisto currently portrays Assistant Special Agent-in-Charge Jubal Valentine in Dick Wolf's CBS drama series FBI.^[32]

Film

Television

Music videos

Soundtrack

• Six Feet Under – (performer: "Daddy Sang Bass") Episode: "Time Flies"

Stage