Keith E. Mostov is an American cell biologist. He received a BA from University of Chicago in 1976 and during 1976–77 he was a Rhodes Scholar at New College, Oxford.[1] Mostov received a PhD in Biological Science from the Rockefeller University in the laboratory of Nobel laureate Günter Blobel in 1983, and an MD from Weill Cornell Medicine in 1984. He was a Whitehead Fellow[2] at the Whitehead Institute of MIT from 1984 to 1989. In 1989, Mostov joined the faculty of the University of California, San Francisco, School of Medicine, where he is currently Professor.[3] Mostov and colleagues discovered and sequenced the Polymeric Immunoglobulin Receptor (pIgR) and proposed the generally accepted model of its pathway and function.[4] Neil E. Simister and Mostov cloned and sequenced the Neonatal Fc Receptor (FcRn).[5] Mostov and colleagues showed how signals in the pIgR direct its polarized trafficking and how polarized MDCK epithelial cells form three-dimensional structures with lumens and tubules.[4] Mostov and colleagues further found how simple rules cause different branching patterns in kidney as compared to other branching tubular organs [6]

Honors and awards

  • Rhodes Scholar [1]
  • Searle Scholar[7]
  • Charles E. Culpeper Foundation Medical Scholar[8]
  • Mallinckrodt Foundation Scholar[9]
  • NIH NIAID MERIT Award[3]
  • American Society for Cell Biology ASCB Fellow[10]

References

  1. 1 2 Burks, Edward C. (1976-09-30). "Rhodes Scholars —From a Playwright to a Soldier— Sail for England". The New York Times. ISSN 0362-4331. Retrieved 2022-01-12.
  2. ↑ "Whitehead Institute of MIT". Whitehead Institute of MIT. Retrieved 2022-01-12.
  3. 1 2 "Keith Mostov, MD, PhD". UCSF Helen Diller Family Comprehensive Cancer Center. Retrieved 2022-01-12.
  4. 1 2 Apodaca, Gerard; Gallo, Luciana I.; Bryant, David M. (December 2012). "Role of membrane traffic in the generation of epithelial cell asymmetry". Nature Cell Biology. 14 (12): 1235–1243. doi:10.1038/ncb2635. ISSN 1476-4679. PMC 3771702. PMID 23196841.
  5. ↑ Parham, Peter (January 1989). "MHC meets mother's milk". Nature. 337 (6203): 118–119. Bibcode:1989Natur.337..118P. doi:10.1038/337118a0. ISSN 1476-4687. PMID 2911346. S2CID 37118328.
  6. ↑ Yu, Wei; Marshall, Wallace F.; Metzger, Ross J.; Brakeman, Paul R.; Morsut, Leonardo; Lim, Wendell; Mostov, Keith E. (2019-09-25). "Simple Rules Determine Distinct Patterns of Branching Morphogenesis". Cell Systems. 9 (3): 221–227. doi:10.1016/j.cels.2019.08.001. ISSN 2405-4712. PMC 7577355. PMID 31557453. S2CID 203569240.
  7. ↑ "Keith E. Mostov". Searle Scholars Program. Retrieved 2022-01-12.
  8. ↑ "mostov / Collections: Charles E. Culpeper Foundation, Inc. records, 1866-2001 - Blacklight Search Results". www.empireadc.org. Retrieved 2022-01-13.
  9. ↑ "Keith Mostov, MD, PhD". UCSF Helen Diller Family Comprehensive Cancer Center. Retrieved 2022-01-12.
  10. ↑ "ASCB Fellows". ASCB. Retrieved 2022-01-12.
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